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杨晓达

教授、博士生导师

杨晓达    教授,博士生导师

北京大学医学部药学院365bet娱乐在线/预防药学实验室

北京市海淀区学院路38号,邮编100191

电话:010-82805611 (办公室)13520451567(手机)

E-mail: xyang@bjmu.edu.cn yxdsohumail@sohu.com

学历1984-1988毕业于北京大学化学系,获理学学士学位。1988-1994毕业于北京大学化学系分析化学专业,获理学博士学位。

工作经历 1994-1996,在北京医科大学药学院无机化学教研室从事博士后研究工作。1997-2000,在美国堪萨斯大学药学院药物化学系,从事博士后研究工作。2000.8回国在北京大学医学部药学院365bet娱乐在线工作,2003年晋升教授,2006-2010年担任365bet娱乐在线副主任。

学术成果和奖励在国内外学术期刊上发表论文100多篇,获得中国发明专利4项,主编“十一五”国家级规划教材1套。获得2004年教育部新世纪优秀人才资助,2002年北京市科技进步二等奖。

学术研究研究金属和无机离子在疾病的发生、发展和传播等病理或生物学过程中作用的化学基础,从而发现具有针对性的无机、天然或有机分子的预防药物。研究内容包括:

¨  代谢性疾病(心血管病、脑神经退行性病变、骨质疏松、糖尿病等)相关的金属代谢和细胞信号转导

¨  细胞的活性氧代谢、抗氧化响应机制和重金属排除

¨  无机和矿物中药的结构-ADMET定量关系(QSPR)研究

¨  从食物和中药中发现和开发肿瘤和代谢性疾病的化学预防药物

近年来,承担或参与了国家自然科学基金面上项目(3)和重点项目(2),科技部项目(2),教育部2111)和985项目(1)和北京市科技计划项目(1)等研究工作。

近年来发表的一些论文:

(1) Wang N, Wang Z, Niu X, Yang X, Synthesis, characterization and anti-diabetic therapeutic potential of novel aminophenol-derivatized nitrilotriacetic acid vanadyl complexes, J. Inorg. Biochem., 2015, 152: 104113
(2) Wang X, Lei R, Huang H, Wang N, Yuan L, Xiao R, Bai L, Li X, Li L, Yang, XThe permeability and transport mechanism of graphene quantum dots (GQDs) across the biological barrier, Nanoscale, 2015, 7: 2034 - 2041
(3) Huang M., Wu Y, Wang N, Wang Z, Zhao P, Yang X, Is the Hypoglycemic Action of Vanadium Compounds Related to the Suppression of Feeding? Biol Trace Elem Res, 2014, 157/3:242-248
(4) Yaling Wu, Meiling Huang, Pan Zhao, Xiaoda Yang
Vanadyl acetylacetonate upregulates PPAR
γand adiponectin expression in differentiated rat adipocytesJBIC2013, 18/6: 623-631
(5) Zhao P, Yang X, Vanadium compounds modulate PPARγactivity primarily by increasing PPARγprotein levels in mouse insulinoma NIT-1 cells, Metallomics, 2013, 5(7): 836-43
(6) Xu Z, Zhang CY, Zhang Y, Yang X, Europium complexes as novel indicators of paracelluar diffusion, Chem. Biodiver., 2012, 9:1916-1922
(7) Gao, Z, Zhang, C, Yu, S, Yang, X, Wang, K, Vanadyl bis-acetylacetonate protected
βcell from palmitate-induced cell death through unfolded protein response pathway, J.Biol.Inorg.Chem., 2011, 16/5: 789-798

(8) Wei, Y, Zhang, C, Zhao, P, Yang, X, Wang, K, A new salicylic acid-derivatised kojic acid vanadyl complex: Synthesis, Characterization and Anti-diabetic Therapeutic Potential, J. Inorg. Biochem. 2011, 105: 10811085
(9) Xia, Q., Feng X-D., Yuan, L., Wang, K., Yang, X., Brain derived neutotrphic factor protects neurons from GdCl3-induced impairment in neuron-astrocyte co cultures, Sci China Chem, 2010, 53: 2193-2199
(10) Zhao Y, Ye L, Liu H, Xia Q, Zhang Y, Yang X, Wang K., Vanadium compounds induced mitochondria permeability transition pore (PTP) opening related to oxidative stress, J. Inorg. Biochem., 2010, 104(4): 371-8
(11) Tian, XJ., Yang, XW., Yang, X., Wang, K., Studies of intestinal permeability of 36 flavonoids using Caco-2 cell monolayer model, Int. J. Pharm., 2009, 367: 58
64

(12) Shen, C., Li, Z., Yang, X., Wang, K., La3+ binds to BiP/GRP78 and induces unfolded protein response in HepG2 cells, Chem-Biol. Interact., 2008, 176: 196-203
(13) Li, M, Li, Y, Chen, J, Wei, W, Pan, X, Liu, J, Liu, Q, Leu, W, Zhang, L, Yang, X, Lu, J, Wang, K, Copper ions inhibit S-Adenosylhomocysteine hydrolase by causing dissociation of NAD+ cofactor, Biochemistry, 2007, 46, 11451-11458
(14) Yu, S., Hu, J., Yang, X., Wang, K., Qian, ZM, La3+-Induced Extracellular Signal-Regulated Kinase (ERK) Signaling via a Metal-Sensing Mechanism Linking Proliferation and Apoptosis in NIH 3T3 Cells, Biochemistry, 2006, 45, 11217-11225
(15) Zhang, Y., Yang, X., Wang, K., Crans, D.C., The Permeability and Cytotoxicity of Insulin-mimetic Vanadium (III, IV, V)-Dipicolinate Complexes, J. Inorg. Biochem, 2006, 100: 80-97
(16) Yu, S., Yuan, L., Yang, X., Wang, K., Qian, Z., La3+-Promoted Proliferation Could Be Interconnected with Apoptosis in NIH 3T3 Cells
J. Cell. Biochem. 2005
94508-519
(17) Yang, X.-G., Yang, X., Yuan, L., Wang, K., Crans, D.C., The Permeability and Cytotoxicity of Insulin-mimetic Vanadium Compounds, Pharm. Res., 2004, 21/6, 1026-1033
(18) Liu, H., Yuan, L., Yang, X., Wang, K., La3+, Gd3+ and Yb3+ induced changes in mitochondrial structure, membrane permeability, cytochrome C release and intracellular ROS level. Chem-Biol. Inter., 2003,146, 27-37