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王欣

副教授、硕士生导师

 

王欣: 博士、副教授、硕士生导师

Tel: 010-82801504   Email: xinwang@bjmu.edu.cn

1991年获北京医科大学应用化学专业学士学位,2002年获北京大学药学院药物化学硕士学位,2010年获得北京大学药学院化学生物学专业博士学位。2004年被聘为副教授,2005年被聘为硕士生导师。2005年1月-2005年6月在悉尼大学做访问学者。

科研主要研究方向为杂环化合物的设计、合成及对神经系统疾病的作用;有机合成新方法的研究。已在Chem. Commun.Bioorg. Med. Chem. Lett., Tetrahedron, Rapid commun. mass spectrum.等国际杂志发表文章二十余篇,另有三项发明专利。主持完成了一项国家自然科学基金面上项目,《哌嗪季铵盐类非成瘾性镇痛药物研究》获2005年北京市科技进步二等奖,为第二完成人。

教学:多年来一直从事有机化学教学工作,曾获2003年及2007年北京大学药学院青年教师讲课比赛一等奖,北京大学第四届及第七届青年教师讲课比赛三等奖。《基础有机化学》课程获北京大学医学部精品课程,为课程负责人。参编译著《杂环化学》。

代表性文章

1)      Xin Wang, Yaowu Sha, Zemei Ge, Wei Wang, Runtao Li*. Fragmentation patterns of novel dithiocarbamate derivatives with pharmaceutical activity under electrospray ionization tandem mass spectrometry conditions. Rapid commun. mass spectrum., 2011, 25(2): 349-354.

2)      Xin Wang, Ang Li, Wei Wang, Runtao Li*. Fragmentation patterns of novel dispirocyclopiperazinium dibromides with strong analgesic activity under electrospray ionization tandem mass spectrometry conditions. Journal of Chinese pharmaceutical sciences, 2011, 20(1): 42-46.

3)      Jin-ming Liu, Xin Wang, Ze-mei Ge, Qi Sun, Tie-ming Cheng, Run-tao Li *。Solvent-free organocatalytic Michael addition of diethyl malonate to nitroalkenes: the practical synthesis of Pregabalin and g-nitrobutyric acid derivatives. Tetrahedron 2011, 67 (3): 636-640.

4)      王欣,刘文俊,李刚,叶加,程铁明,李润涛*. 双螺环哌嗪季铵盐类化合物的合成及镇痛活性研究 有机化学2010, 30(10): 1559-1562.

5)      Junfeng Wang, Xin Wang, Zemei Ge,* Tieming Cheng and Runtao Li.* Highly enantioselective Michael addition of cyclopentanone with chalcones via novel di-iminium mechanism. Chem. Commun., 2010, 46: 1751-1753.

6)      Xin Ai, Xin Wang*, Jin-ming Liu, Ze-mei Ge, Tie-ming Cheng, Run-tao Li* An effective Aza-Michael addition of aromatic amines to electron-de?cient alkenes in alkaline Al2O3. Tetrahedron, 2010, 66 (29): 5373-5377.

7)      Shuai Xia, Xin Wang,*  Ze-mei Ge, Tie-ming Cheng, Run-tao Li* An Efficient Synthesis of aryldithiocarbamic acid esters from Michael addition of electron-deficient alkenes with arylamines and CS2 in solid media alkaline Al2OTetrahedron, 2009, 65 (5): 1005-1009

8)      Ang Li, Xin Wang, Cai-Qin Yue, Jia Ye, Chang-Ling Li and Run-Tao Li* Unique spirocyclopiperazinium salt. Part 4: Modification of dispirocyclopiperazinium (DSPZ) salts as analgesics,Bioorg. Med. Chem. Lett., 2007, 17: 5078–5081;

9)      Xin Wang, Yaowu Sha, Xueling Hou, Runtao Li. Electrospray ionization tandem mass spectrometric analysis of fragmentation patterns of dithiocarbamate derivatives. Rapid commun. mass spectrum., 2006; 20: 719-722.

10)   Xin Wang, Yaowu Sha, Runtao Li. Fragmentation patterns of novel dispirocyclopiperazinium dibromides with strong analgesic activity under electrospray ionization tandem mass spectrometry conditions. Rapid commun. mass spectrum., 2004; 18: 829-833.

11)   Xin Wang, Yaowu Sha, Runtao Li. Fragmentation patterns of novel dispirocyclopiperazinium dibromides with strong analgesic activity under electrospray ionization tandem mass spectrometry conditions. Int. J Mass Spectrom., 2004; 235: 111–115.

12)   Xin Wang, Feng-Li Gao, Hong-Bin Piao, Tie-Ming Cheng, Run-Tao Li. Unique spirocyclo- piperazinium salt. Part 2: Synthesis and structure-activity relationship of dispirocyclo- piperazinium salts as analgesics. Bioorg. Med. Chem. Lett., 2003, 13:1729-1732.

13)     Feng-Li Gao, Xin Wang, Hong-Mei Zhang, Tie-Ming Cheng, Run-Tao Li. Unique spirocyclo- piperazinium salt I: Synthesis and structure-activity relationship of spirocyclopiperazinium salts as analgesics. Bioorg. Med. Chem. Lett., 2003, 13: 1535-1537.

14)    Jing-Chao Dong, Xin Wang, Run-Tao Li, Hong-Mei Zhang, Tie-Ming Cheng, and Chang-Ling Li. Synthesis and analgesic activity of hydrochlorides and quaternary ammoniums of epibatidine incorporated with amino acid ester. Bioorg. Med. Chem. Lett., 2003, 13: 4327-4329.