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李庆

副教授、硕士生导师

 

李庆:副教授,硕士生导师

电话:010-82801714

E-mail: qli@bjmu.edu.cn

通信地址:北京市海淀区学院路38号药学楼522室 邮编:100191

1983.9-1987.7,兰州大学化学系有机化学专业,学士学位;1987.8-1991.11,大庆石油化工总厂研究院,助理工程师;1991.11-1996.8,大庆油田设计院,工程师;1993.9-1996.7,天津大学化学系精细化工专业,硕士学位;1996.9-1999.7,北京医科大学药学院药物化学专业,博士学位。自1999年至今,北京大学医学部药学院365bet娱乐在线工作。目前主要开展抗粘附多价寡糖及糖-肽杂合物的合成研究, 设计合成了结构多样的多价寡糖及糖-肽杂合物,其中四价乳糖Gu-4具有良好的抗白细胞-内皮细胞粘附活性,作为药物候选分子在对大鼠的重症烧伤休克、脓毒症及关节炎的治疗中已显示了良好的效果。

目前在研课题:

1.乳糖衍生物抗粘附新靶点的发现及其抗炎机制的研究 (90713004),国家自然科学基金重大研究计划“基于化学小分子探针的信号转导过程研究”培育项目,2008.1~2010.12。

2. 新型“多配体”型杂合糖簇的设计、合成及“杂簇螯合效应”的探索(21172015),国家自然科学基金面上项目,2012.01~2015.12。。

近年发表的相关论文:

1.Qing Li, Bin Su, Hui Li, Xiang-Bao Meng, Meng-Shen Cai, Zhong-Jun Li, Ta-Lin Suo, Rou-Li Zhou, Synthesis and potential activity in anti-metastasis of spacer armed 2-acetamido-2-deoxy-4-O-b-D-galactopyranosyl-D-glucosides and their dimers, Carbohydrate Research, 2003, 338, 207-217.

2.Shu Chun Li, Li Min Niu, Hui Li, Zhong Jun Li, Qing Li*, Synthesis of RGD-aPEG-Lactoside, a Potential Anti-metastasis Glycoconjugate, Chin. Chem. Lett., 2004, 15, 532-534.

3.Zhao-Jun Yin, Qing Li*, Xiang-Bao Meng and Zhong-Jun Li*, Design and Synthesis of Novel Multivalent Mannosides Targeting Mannose Receptor, Carbohydrate Research, 2007, 342, 2729-2734.

4.Chen Li, Xiang-Bao Meng, Xiao-Feng Jin, Zhong-Jun Li and Qing Li* , Synthesis of allyl 4-O-{3-deoxy-3-[4-benzylaminocarbonyl-1H-(1,2,3)-triazol-1-yl]-β-D-galactopyranosyl}-2-deoxy-2-acetamido-β-D-glucopyranoside as a potential inhibitor of   galectin-3, Journal of Chinese Pharmaceutical Sciences, 2008, 17, 209-214.

5. Zhihui Zhao & Qing Li & Jiale Hu & Zhongjun Li & Jinghua Liu & Aihua Liu & Peng Deng & Lin Zhang & Xiaowei Gong & Kesen Zhao & Shuangquan Zhang & Yong Jiang, Lactosyl derivatives function in a rat model of severe burn shock by acting as antagonists against CD11b of integrin on leukocytes, Glycoconjugate J., 2009, 26, 173-188.

6.Yu Zheng, Xiang-bao Meng, Shu Chun Li, He-Qing Hang, Zhong-jun Li*, Qing Li*

Synthesis and anti-tumor activities of 5-carbohydrate modified cyclophosphamide derivates, Journal of Chinese Pharmaceutical Sciences, 2010, 19, 327-340.

7.  Qing Li, Yuetao Zhao, Xiangbao Meng, Tingting Yan, Zhihui Zhao, Zhongjun Li, Synthesis of two multivalent lactosides with anti-adhesive activity and their fluorescein-labeled and biotin-labeled derivatives, Journal of Chinese Pharmaceutical Sciences, 2011, 20, 325-334.

8.李中军, 李庆,赵智辉,孟祥豹,李树春,一类抗粘附活性的乳糖簇及其荧光标记物, 中国专利ZL 200610078665X.

9.赵智辉,陈元,褚键,王良哲,李中军, 李庆,乳糖衍生物的新用途,中国专利 ZL 03112879.3.