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葛泽梅

副教授、硕士生导师

葛泽梅副教授,硕士生导师。

Tel: 010-82801504
E-mail: zmge@bjmu.edu.cn

通讯地址:北京市海淀区学院路38号药学楼504      邮编:100191

多年来一直从事有机化学、药物化学、化学生物学的科研与教学工作。主要研究方向为基于作用机制的杂环类化合物的设计、合成、合成方法及生物活性研究。已主持完成国家自然科学基金2项,作为主要参加者完成国家自然科学基金3项以及“973”子课题等。目前主持或承担国家“十一五”北京大学综合性创新药物研究开发技术大平台的候选药物研究品种及新药临床前研究课题。在国内外学术刊物上发表论文40余篇,申请专利6项。

主要研究领域:

1.      基于作用机制的杂环类化合物的设计、合成、合成方法及生物活性研究

2.      氨基二硫代甲酸酯类化合物的设计、合成及抗肿瘤活性研究

3.      新型酪氨酸激酶抑制剂的设计、合成及活性研究

4.      硫醇替代试剂的应用扩展与研究

代表性论文

1.         Ri-Dong Li, Xin Zhang, Qiao-Yan Li, Ze-Mei Ge*, Run-Tao Li* ,Novel EGFR inhibitors prepared by combination of dithiocarbamic acid esters and 4-anilinoquinazolines. Bioorg. Med. Chem. Lett. 2011, 21, 3637–3640.

2.         Wang, Junfeng; Qi, Chao; Ge, Zemei*; Cheng, Tieming; Li, Runtao*. Efficient direct asymmetric vinylogous Michael addition reactions of ?g -butenolides to chalcones catalyzed by vicinal primary-diamine salts Chem. Commun., 2010, 46, 2124–2126 .

3.         Wang, Junfeng; Li, Qin; Qi, Chao; Liu, Yi; Ge, Zemei*; Li, Runtao*. Primary 1,2-diamine catalysis III: an unexpected domino reaction for the synthesis of multisubstituted cyclohexa-1,3-dienamines. Organic & Biomolecular Chemistry,  (2010),  8(19),  4240-4242.

4.         Wang, Junfeng; Wang, Xin; Ge, Zemei*; Cheng, Tieming; Li, Runtao*. Highly enantioselective Michael addition of cyclopentanone with chalcones via novel di-iminium mechanism. Chem. Commun., 2010, 46, 1751–1753 .

5.         MENG LEI, SHUAI XIA, JUNFENG WANG, ZEMEI GE,* TIEMING CHENG, AND RUNTAO LI*An Efcient Dipeptide-Catalyzed Direct Asymmetric Aldol Reaction of Equimolar Reactants in Solid MediaCHIRALITY, 22:580–586 (2010).

6.         Fang-bin Han,Ze-mei Ge,*Tie-ming Cheng,Run-tao Li* ,Novel One-Pot, Four-Component Synthesis of 3-Alkyldithiocarbonyl-oxazolidines from Aminoethanols, Ketones, Carbon Disulfide, and Halides, Synlett., 2009, 4, 648-650.

7.         Zhong-qing Wang, Ze-mei Ge,* Tie-ming Cheng, Run-tao Li*, Synthesis of Highly Substituted Pyridines via a One-Pot, Three-Component Cascade Reaction of Malononitrile with Aldehydes and S-Alkylisothiouronium Salts in Water, Synlett., 2009, 7, 2020-2022.

8.         Jun-feng Wang, Meng Lei, Qin Li, Ze-mei Ge,* Xin Wang, Run-tao Li*, A novel and ef?cient direct aldol condensation from ketones and aromatic aldehydes catalyzed by proline–TEA through a new pathway, Tetrahedron.65(2009), 4826-4833

9.         ZHU, Jirang(朱继让), LI, Ridong(李日东), GE, Zemei*(葛泽梅), CHENG, Tieming(程铁明), LI, Runtao*(李润涛),  Synthesis of β-Hydroxy Sulfides via Thiolysis of Epoxides Using S-Alkylisothiouronium Salts as Thiol Equivalents in Basic Aqueous Medium, Chinese Journal of Chemistry, 2009, 27, 791-796.

10.     WANG, Zhongqing(王仲清), GE, Zemei*(葛泽梅), CHENG, Tieming(程铁明), LI, Runtao*(李润涛), An Efficient Four-Component, One-Pot Synthesis of  Poly-Substituted Pyrimidines in Water, Chinese Journal of Chemistry, 2009, 27, 834-838.

11.     XuYan, Ze-Mei Ge*,Tie-Ming Cheng and Run-Tao Li*, One-pot synthesis of 1,3,4-oxadiazole-5-thioethers in water, Journal of Chinese Pharmaceutical Sciences 17 (2008 ) 277-280.

12.     Song-wen Lin,a Qi Sun,a Run-tao Li,*a,b Tie-ming Cheng,a Ze-mei Ge*a, Potassium Phosphate Promoted Aza-Markovnikov Addition of N-Heterocycles to Vinyl Esters. Synthesis, 2007, 13, 1933-1938.

13.     Yan Zhao,a Ze-Mei Ge,*a Tie-Ming Cheng,a Run-Tao Li*a,b, Thia-Michael Addition Using Cheap and Odorless S-Alkylisothiouronium Salts as Thiol Equivalents in Water. Synlett.,  2007, 10, 1529-1532.

14.     Qi Sun, Run-Tao Li, Wei Guo, Jing-Rong Cui, Tie-Ming Cheng and Ze-Mei Ge,* Novel class of cyclophosphamide prodrug: Cyclophosphamide spiropiperaziniums (CPSP), Bioorganic & Medicinal Chemistry Letters, 2006, 16, 3727-3730.

15.     GE, Ze-Mei, LI, Qin, ZHENG, Shao-Jun, CHENG, Tie-Ming, CUI, Yu-Xin, LI, Run-Tao*, Facile One-pot Synthesis of Ethyl 3-Alkyl-4-hydroxy-2-thioxothiazolidine-4-carboxylates, Chinese Journal of Chemistry, 2006, 24, 381-385.

16.     Ze-mei Ge, Jia-ling Cui, Yan-ling Wang, Tie-ming Cheng, Run-tao Li*. A mild and efficient synthesis of 4, 5-disubstituted 3-amino-4-hydroxythiazolidine-2-thiones and S, N- disubstituted 1, 3, 4- thiadiazole-2-thiones. Synthesis, 2004, 8, 1257-1261.