您目前的位置: 首页» 365bet娱乐在线改版» 师资队伍» 教授

李中军

教授、博士生导师

 

李中军药物化学博士,教授,博士生导师;北京大学药学院365bet娱乐在线 主任

电话(010)-8280 1714 (办公室)        传真(010)-8280 5496

E-mail: zjli@bjmu.edu.cn

通讯地址:北京市海淀区学院路38号北京大学医学部药学楼503      邮编100191

1982~1987年就读于北京医科大学药学院化学专业获理学学士学位,1987-1992年就读于北京医科大学药学院药物化学专业获药物化学博士学位,后留校任教从事教学和科研工作。1999年被聘为教授,2001年被聘为博士生导师1994年起,先后获得了国家自然科学基金重大专项、重点课题、面上项目、科技部“973、科技部创新药物重大专项、国家新药研究基金、卫生部科研基金、教育部创新团队等三十项基金的支持。长期以来从事糖化学、糖化学生物学及相关创新药物的研究。已发表学术论文100余篇和专著一部,申报中国专利15项,已获授权8项。担任Chinese Chemical Letter、化学通报、中国药学(英)编委。已指导研究生60余人获得学位。曾获国家教委科技进步三等奖及中国药学会-Servier青年药物化学奖。目前承担的课程有“有机合成”(药学院本科)、糖化学(药学院研究生)。先后获得医学部首届最受学生欢迎“十佳教师”、研究生“良师益友”及“我身边的好老师”等称号。 

研究方向与兴趣:

· 寡糖合成方法学及快速组装策略研究

· 基于糖类的选择性合成研究

· 糖化学生物学研究

· 创新药物研究

代表性论文和专著

1.  Gang Wang, Zhong-Jun Li, Xiang-Bao Meng, Highly Efficient and Diastereoselective Povarov-like Reaction Involving O-pivaloylated D-galactosylimine, Adv. Synth. Catal., 2013, 355, 303-307.

2.  Wenxuan Zhang, Ying Chen, Qingzhao Liang, Hui Li, Hongwei Jin, Liangren Zhang, Xiangbao Meng, Zhongjun Li, Design, Synthesis and Antibacterial Activities of Conformationally Constrained Kanamycin A Derivatives, J. Org. Chem., 2013,78, 400-409.

3.  Tian Tian, Wen-He Zhong, Shuai Meng, Xiangbao Meng, Zhongjun Li, Hypervalent iodine mediated para-selective fluorination of anilides, J. Org. Chem., 2013, 78, 728-732.

4.  Wenxuan Zhang, Qingzhao Liang, Hui Li,Xiangbao Meng, Zhongjun Li, Concise synthesis and antitumor activity of Bengamide E and its analogs, Tetrahedron, 2013,69, 664-672.

5.  Shasha Li, Wenhe Zhong, Zhongjun Li, Xiangbao Meng, Unprecedented synthesis,invitro and in vivo anticancer evaluation of novel triazolonaphthalimide derivatives, Eur. J. Med. Chem., 2012, 47, 546-552.

6.  Wenhe Zhong, Shan Liu, Jun Yang, Xiangbao Meng, Zhongjun Li, Metal-Free, Organocatalytic Syn Diacetoxylation of Alkenes, Org. Lett., 2012, 14, 3336-3339.

7.  Yang Yang, Xiaochao Xue, Xiaofeng Jin, Lijun Wang, Yinlin Sha, Zhongjun Li, Synthesis of multivalent N-acetyl lactosamine modified quantum dots for the study of carbohydrate and galectin-3 interactions, Tetrahedron, 2012, 68, 7148-7154.

8.  Tingting Yan, Qing Li, Huiting Zhou, Yuetao Zhao, Shuqin Yu, Guang lin Xu, Zhimin Yin, Zhongjun Li, Zhihui Zhao, Gu-4 Suppresses Affinity and Avidity Modulation of CD11b and Improves the Outcome of Mice with Endotoxemia and Sepsis, PloS ONE, 2012, 7(2), e30110.

9.  Jie Fan, Huiting Zhou, Shihui Wang, Hailian Wang, Yushun Zhang, Yingtao Guo, Qing Li, Zhongjun Li, Zhihui Zhao, Therapeutic effects of lactosyl derivative Gu-4 in a collagen- induced arthritis rat model, Glycoconj. J., 2012, 29, 305-313.

10.  Zhi-Qi Lao, Wen-He Zhong, Qing-Hua Lou, Xiang-Bao Meng, Zhong-Jun Li, KI-Catalyzed Imidation of Unactived sp3 C-H Bonds Adjacent to an Amide Nitrogen Atom, Org. Biomol. Chem., 2012, 10, 7869-7871.

11.  Qing Wang, Wenhe Zhong, Xiong Wei, Maoheng Ning, Xiangbao Meng, Zhongjun Li, Metal-Free Intramolecular Aminofluorination of Alkenes Mediated by PhI(OPiv)2/ Hydrogen Fluoride-Pyridine System, Org. Biomol. Chem., 2012, 10, 8566-8569.

12.  Yangbing Li, Zhaojun Yin, Bo Wang, Xiang-Bao Meng, Zhong-Jun Li, Synthesis of Orthogonally Protected L-Hexoses from D-Glucose, Tetrahedron, 2012, 68, 6981-6989.

13. Yunfeng Li, Yao Meng, Xiangbao Meng, Zhongjun Li, Stereoselective synthesis of polyoxygenated linear diaza-triquinanes via intramolecular 1,3-dipolar cycloaddition of sugar-derived hex-5-enals, Tetrahedron, 2011, 67, 4002-4008.

14. Boyu Li, Gang Wang, Zhongjun Li, Xiangbao Meng, InCl3-Catalyzed Synthesis of C-Pyrrolyl Glycosides in water: Tandem Condensation of Aminosugars and 1,3-Dicarbonyl Compounds through Carbocation Intermediates, Tetrahedron Lett., 2011, 52, 3891–3894.

15. Qing Ma, Sheng Sun, Xiang-Bao Meng, Shu-Chun Li, Zhong-Jun Li, Assembly of Homolinear α(1→2)-Linked Nonamannoside on Ion Liquid Support, J. Org. Chem., 2011, 76, 5652-5660.

16. Bo Wang, Zhaojun Yin, Yangbing Li, Ting-Xiang Yang, Xiang-Bao Meng, Zhong-Jun Li, An Active Cobalt Catalyst for the Cleavage of Benzyl Ether, J. Org. Chem., 2011, 76, 9531-9535.

17. Wenhe Zhong, Jun Yang, Xiangbao Meng,  Zhongjun Li, Diastereoselective Diacetoxylation of Alkenes Mediated by PhI(OAc)2/BF3?OEt2 System, J. Org. Chem., 2011, 76, 9997-10004.

18.  Zhao-Jun Yin, Bo Wang, Yang-Bing Li, Xiang-Bao Meng, Zhong-Jun Li, A Highly Efficient and Mild Method for Regioselective de-O-benzylation of Saccharides by Co2(CO)8-Et3SiH-CO Reagent System,Org. Lett., 2010, 12, 536-539.

19. Yang Yang, Yuetao Zhao, Tingting Yan, Min Yu, Yinlin Sha, Zhihui Zhao, Zhongjun Li, Design and fabrication of multivalent gal-containing quantum dots and study of its interactions with a sialo- glycoprotein receptor (ASGP-R), Tetrahedron Lett., 2010, 51, 4182–4185.

20. Yang Yang, Min Yu, Tingting Yan, Zhihui Zhao, Yinlin Sha, Zhongjun Li, Characterization of multivalent lactose quantum dots and its application in carbohydrate-protein interactions study and cell imaging, Bioorg. Med. Chem., 2010, 18, 5234–5240.

21. Min Yu, Yang Yang, Rongcheng Han, Qiang Zheng, Lijun Wang, Yuankai Hong, Zhongjun Li, Yinlin Sha, Polyvalent Lactose-Quantum Dot Conjugate for Fluorescent Labeling of Live Leukocytes, Langmuir, 2010, 26, 8534–8539.

22. 蔡孟深,李中军主编,“糖化学”,化学工业出版社,北京,2007.